Podcast Episodes
108 episodes from 30 health podcasts covering blood test interpretation and biomarker optimization.
AMA #14:What lab tests can (and cannot) inform us about longevity
Peter discusses the lab tests he runs with every patient and what they reveal about longevity, including which biomarkers matter most
AMA #43:Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for CVD
Deep dive into ASCVD risk factors including apoB, LDL, hyperinsulinemia, and Lp(a), explaining mechanisms by which they confer risk
Training for The Centenarian Decathlon:zone 2, VO2 max, stability, and strength
Training protocols for longevity including zone 2 cardio, VO2 max work, and strength training with discussion of fitness biomarkers
Understanding cardiovascular disease risk, cholesterol, and apoB
Compilation episode covering cardiovascular disease
Exercising for longevity:strength, stability, zone 2, zone 5, and more
Why training in zone 2 and zone 5 is important, primer on VO2 max, and most effective ways to engage in those types of exercise
Dr. Casey Means:Transform Your Health by Improving Metabolism &Blood Sugar Regulation
Comprehensive discussion of metabolic health biomarkers, continuous glucose monitoring, and optimizing metabolism through lifestyle
Dr. Rhonda Patrick:Micronutrients for Health &Longevity
Discussion of key micronutrients for health including vitamin D, omega-3s, and other essential nutrients tracked via blood work
Check These Biomarkers on Your Next Blood Test
Rhonda covers key biomarkers for metabolic health, inflammation, omega-3 status, thyroid function, and gut health
How Vitamin D, Omega-3s, &Exercise May Increase Longevity
Discussion of vitamin D deficiency risks, omega-3 benefits, and exercise effects on longevity biomarkers
The Powerful Longevity Benefits of Omega-3
Deep dive into omega-3 fatty acids and their effects on cardiovascular health, brain function, and inflammation
Vitamin D's role in immune function
How vitamin D regulates immune function and why deficiency leads to inflammation and disease
Does omega-3 reduce cardiovascular disease? Comparing major trials
Analysis of major omega-3 trials including REDUCE IT, VITAL, and STRENGTH with discussion of biomarker changes
Peter Attia discusses biomarkers associated with risk of leading diseases
Peter Attia shares his comprehensive panel of biomarkers for assessing disease risk and optimizing healthspan
A Deep Dive Into How To Interpret The Results Of Your Blood Testing
Comprehensive guide to interpreting blood test results including hormones, metabolic markers, and inflammatory markers
Cortisol Decoded:The Myths &Truths About A Hormone Crucial To Your Health
Dr. Craig Koniver discusses cortisol biochemistry, effects on exercise and longevity, and ways to modulate cortisol
7 Signs Your Cortisol and Adrenals Are Broken
Discussion of adrenal dysfunction with saliva testing protocols showing improvements in DHEA-S and testosterone
Why Is My Cortisol High Even Though I'm Doing Everything Right? The DUTCH Test
Comprehensive analysis of the DUTCH test including hormone metabolites and cortisol patterns
Testosterone Replacement Therapy, Hormone Testing 101, and More
Adam Lamb discusses comprehensive hormone testing including testosterone, thyroid, and metabolic markers
Best Of Hormone Health
Compilation of best insights on balancing cortisol, enhancing growth hormone, and optimizing sex hormones
Which Lab Tests are Essential?
Chris discusses the lab tests he runs with every patient and what they reveal about root causes of health problems
Understanding the Gut-Thyroid Axis, Hypothyroidism, and Hashimoto's
Dr. Michael Ruscio discusses thyroid biomarkers and the connection between gut health and thyroid function
Episode 171:July 2022 Bloodwork Review
Paul reviews his personal bloodwork results after following a carnivore/animal-based diet
Sky High LDL on Keto/Carnivore:Should You Worry?
Dr. Nadir Ali discusses why LDL goes up on keto/carnivore diets and whether high LDL is concerning
When You Should Worry About LDL Cholesterol
Mike Fave and Paul challenge conventional views on LDL cholesterol and explore metabolic health markers
Episode 385:Carnivore Diet and Dr. Baker's Blood Work
Robb Wolf and Dr. Shawn Baker discuss all-meat diets and review Dr. Baker's blood work after 15 months carnivore
Your Lab Tests Are Normal But You Feel Sick:What Your Doctor Is Missing
Dr. Hyman discusses why conventional lab reference ranges miss early disease and what optimal ranges should be
Is Your Thyroid the Hidden Root Cause of Your Health Issues?
Comprehensive thyroid testing and the impact of toxins and stress on thyroid function with practical optimization tips
Are You Pre-Diabetic? Know Your Numbers
Dr. Hyman covers measuring insulin levels, understanding A1C, and optimal lab ranges for metabolic health
How Insulin Resistance Drives Fatty Liver, Cognitive Issues, and Metabolic Syndrome
Dr. Ben Bikman discusses how insulin resistance leads to metabolic dysfunction and what biomarkers reveal
The Hidden Epidemic of Low Thyroid Function
Why millions have undetected thyroid issues and how functional medicine treats thyroid dysfunction
Insulin Resistance:Key Signs &Indicators You Need To Know
Thomas DeLauer discusses insulin resistance indicators and how to combat it through lifestyle changes
Blood sugar hacks to give you more energy with Glucose Goddess
Jessie Inchauspé discusses latest science around glucose control and continuous glucose monitors
How to control blood sugar spikes
Biochemist Jessie Inchauspé and Dr. Sarah Berry discuss practical strategies for blood sugar control
Why Is Type 2 Diabetes So Widespread?
Discussion covering insulin's role as a hormone and how it regulates blood sugar levels
How to improve blood sugar control with exercise
How exercise affects blood sugar spikes and crashes with practical implementation strategies
How to Uncover Hidden Hormone Imbalances
Dr. Stephen Cabral analyzes hormone profiles on air discussing thyroid issues and hormone optimization
Test Your Sex Hormones &Cortisol at Home
Dr. Cabral discusses proper timing for blood work to get accurate lipid profiles and thyroid levels
Master Your Blood Glucose To Enhance Immunity, Sexual Function, &Longevity
Dr. Casey Means discusses how glucose levels influence skin, mood, inflammation, and body composition
How Metabolism Works &The Truth About Inflammation
Discussion of how ultraprocessed foods impact metabolic efficiency and inflammatory biomarkers
How Out of Control Blood Sugar Contributes to Body Fat, Brain Fog, and Alzheimer's
Dr. Ronesh Sinha discusses insulin resistance, role of ethnicity on metabolism, and lifestyle changes to address dysfunction
How Insulin Resistance Destroys Your Brain and Body
Dr. Benjamin Bikman discusses prevalence of insulin resistance and solutions to reverse pre-diabetes and improve brain function
Sugar Is Making Us Fat, Tired, and Sick
Metabolic health discussion covering cardiovascular health, cognition, mood, and fertility
5 powerful takeaways from Dave Asprey on lab testing
Discussion with Lola Priego of Base about at-home biomarker testing to solve symptoms and optimize health
Bryan Johnson's Blueprint:The 11 Biomarkers for Longevity
Bryan Johnson discusses the 11 key biomarkers he tracks with Dr. Mike Mallin to stay biologically young
Science-Backed Wellness:Thomas DeLauer on Ketosis, Fasting, and Sustainable Health
Discussion of science behind fitness and nutrition including ketosis, intermittent fasting, and metabolic markers
Thomas DeLauer on Insulin Resistance, Keto, and Intermittent Fasting
Discussion of Thomas's weight loss journey and optimization of metabolic biomarkers through diet and fasting
Meal Timing With Thomas DeLauer
Episode covering meal timing, keto meals, ways to lower blood sugar naturally, and glucose-friendly sugar substitutes
Carnivore Diet:Performance and Biomarkers
Dr. Shawn Baker discusses how carnivore diet impacted his biomarkers and athletic performance
Heart Rate Variability and Recovery Optimization
Discussion of HRV as key biomarker of recovery, stress, and overall health with methods to improve it
Dr. Andy Galpin:Maximize Recovery To Achieve Fitness &Performance Goals
Comprehensive discussion of recovery biomarkers and how to track and optimize recovery for performance
Peter Attia's 80% Zone 2, 20% VO2 Max Training Protocol
Discussion of Peter Attia's cardio training protocol and the biomarkers that track cardiovascular fitness
#334 - Cardiovascular disease:development, biomarkers, apoB, cholesterol, brain health | Tom Dayspring
Tom Dayspring explores atherosclerosis foundations, why apoB is a superior metric for CVD risk, the role of insulin resistance and chronic kidney disease, and cholesterol's impact on brain health
AMA #78:Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health
Why high apoB deserves treatment even in metabolically healthy patients with CAC score of zero, managing hypertension, assessing metabolic health beyond HbA1c with fasting insulin and lactate
AMA #76:Longevity drugs, aspirin for CVD, and strategies to improve muscle mass
Peter evaluates longevity drugs using proven/promising/fuzzy/noise/nonsense scale, discusses GLP-1 receptor agonists like Ozempic, low-dose aspirin evidence for CVD prevention, and protein optimization
Transform Your Metabolic Health &Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Stanford geneticist discusses glucotypes - individual glucose response patterns, why no single diet works for everyone, continuous glucose monitoring insights, and personalized medicine based on genes and microbiome
Q&A #72:Fragmented sleep, lipid biomarkers including ApoB and Lp(a), statins and Repatha
Rhonda discusses key lipid markers associated with atherosclerosis including apoB and Lp(a), questions about statins and PCSK9 inhibitors like Repatha, plus sleep fragmentation effects
Aliquot #109:Reducing ApoB with diet, drugs, and supplements
Deep dive into apolipoprotein B as a robust predictor of cardiovascular disease risk, with practical strategies for lowering apoB through dietary changes, medications, and targeted supplements
Don't Die Podcast #4:The Biomarker Strategy That Made Bryan Johnson the World's Healthiest Human
Bryan and Dr. Mike Mallin share the comprehensive biomarker strategy behind Blueprint protocol, covering the 11 key markers Bryan tracks to stay biologically young and optimize 81 organ ages
#46 - Chris Masterjohn:Choline, TMAO, methylation, MTHFR, fatty liver, and more
Deep dive into choline deficiency and NAFLD, the controversial TMAO hypothesis and cardiovascular risk, methylation pathways, MTHFR variants, and why the science on TMAO may be overstated
Dr. Ronald Krauss:LDL Cholesterol, Particle Size, Heart Disease &Atherogenic Dyslipidemia
World-renowned lipidologist explains why small dense LDL particles are more atherogenic, how they become oxidized in artery walls, and the relationship between refined sugar and LDL particle size
AMA #54:Magnesium:risks of deficiency, supplement options, cognitive and sleep benefits
Comprehensive magnesium episode covering why deficiency is common, testing methods, optimal supplementation forms (threonate, glycinate, oxide), and benefits for bone health, nerve function, glucose control, and sleep
AMA #58:Iron:its role in health, testing methods, and managing iron deficiency
Essential iron episode explaining ferritin vs serum iron testing, symptoms of deficiency vs anemia, who is most susceptible, and strategies for supplementation and infusion
AMA #49:Heart rate recovery, strength training, rucking, kidney function, and brain health
Deep dive into kidney health markers including why cystatin C is superior to creatinine, how kidney function impacts longevity, the five stages of kidney disease, and strategies to slow decline
AMA #37:Bone health—everything you need to know
Comprehensive bone health episode covering bone mineral density, calcium metabolism, vitamin D optimization, PTH function, and how estrogen affects bone remodeling throughout life
The Best Diet to Reverse Fatty Liver Disease
Dr. Yousef Elyaman explains GGT as marker of glutathione depletion and oxidative stress, how elevated ALT/AST indicate liver damage, and functional medicine approaches to reversing fatty liver
Dr. Natalie Crawford:Female Hormone Health, Fertility &Vitality
Fertility specialist explains AMH testing for ovarian reserve, FSH and LH roles in ovulation, egg freezing timing, how birth control affects hormones, and key nutrients for fertility
Zinc deficiency and high copper-to-zinc ratios link to Alzheimer's disease | Dale Bredesen
Dr. Dale Bredesen discusses metabolic profiling showing zinc deficiency in Alzheimer's patients, the importance of copper-zinc balance, and how imbalances affect brain health
#322 - Bone health for life:building strong bones, preventing age-related loss | Belinda Beck
Exercise scientist explains osteoblast and osteoclast function, how to build peak bone mass, gender differences in bone mineral density, and the roles of calcium, vitamin D, and PTH in bone remodeling
AMA #46:Optimizing brain health:Alzheimer's disease risk factors, APOE, prevention strategies
Deep dive into brain health covering how Alzheimer's is diagnosed, blood-based biomarkers significance, what APOE gene variants mean for risk, and prevention strategies including exercise, nutrition, lipid management, sauna, and oral health
#252 - Latest insights on Alzheimer's disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick
Discussion of APOE-ε4 allele risk for Alzheimer's (twofold to tenfold increased risk), connection between type 2 diabetes and dementia, blood-brain barrier dysfunction, and latest research on cancer prevention
AMA #56:Cancer screening:pros and cons, screening options, interpreting results
Comprehensive cancer screening episode examining arguments for and against screening, PSA interpretation, CA-125 for ovarian cancer, multi-cancer early detection tests, and understanding sensitivity, specificity, and predictive values
#273 - Prostate health:cancer prevention, screening, treatment | Ted Schaeffer
Deep dive into PSA as a screening tool, how to interpret results, MRI as secondary screening, prostate biopsy options, how androgens and genetics contribute to prostate cancer, and treatment options including surgery
How to Control Your Metabolism by Thyroid &Growth Hormone
Explains how T3 and T4 thyroid hormones regulate metabolism, the critical roles of iodine and selenium in thyroid function, L-tyrosine requirements, and why Brazil nuts are the best selenium source
Using Salt to Optimize Mental &Physical Performance
How sodium is essential for neurons and action potentials, the relationship between salt intake and stress response, blood pressure regulation, and optimal sodium-to-potassium ratios for performance
Dr. Andy Galpin:Optimal Nutrition &Supplementation for Fitness
The Galpin hydration equation, electrolyte ratios for athletic performance, why proper sodium-potassium-magnesium balance is foundational for cellular function, and hydration strategies for different training phases
Personalize Your Nutrition Based on Genetics
How gene polymorphisms affect nutrient absorption including MTHFR and folate metabolism, FUT2 and vitamin B12, optimal methylfolate supplementation for reducing homocysteine, and personalized nutrition strategies
Dr. Chris Shade:Heavy Metal Toxicity, Mercury Sources, and Detoxification
Mercury speciation expert explains the big 4 toxic heavy metals (mercury, lead, cadmium, arsenic), symptoms of toxicity, how metals affect mitochondria and antioxidant pools, and safe detoxification protocols
#337 - Insulin resistance masterclass:metabolic dysfunction prevention, diagnosis, treatment | Ralph DeFronzo
Defining insulin resistance and its effects on glucose, fat, and protein metabolism, how it varies between healthy, obese, and diabetic individuals, hyperinsulinemia dangers, and tissue-specific manifestations
#24 - Tom Dayspring:Inflammation, oxLDL, Lp-PLA2, remnants, and cardiovascular risk
Lipidologist discusses inflammation and endothelial health biomarkers, oxidative stress in cardiovascular disease, Lp-PLA2 as marker of active plaque formation, and when aggressive treatment is needed
Understanding cholesterol:going beyond total LDL + HDL | Ronald Krauss
Why the simplified HDL-good LDL-bad view is misleading, how VLDL gives rise to LDL, non-HDL cholesterol as atherogenic marker, and why total cholesterol alone doesn't predict cardiovascular risk
Healing Autoimmune Disease Using A Functional Medicine Approach
Why autoimmune conditions are rising, functional medicine approach to treating rheumatoid arthritis, lupus, and other conditions, understanding ANA testing, and how to identify root causes of autoimmunity
Female Hormone Health, PCOS, Endometriosis, Fertility &Breast Cancer | Dr. Thaïs Aliabadi
Board-certified OB/GYN explains PCOS and endometriosis as common causes of infertility, hormone testing including prolactin, evidence-based treatments, and supplement and lifestyle interventions
#02 - Rhonda Patrick:the IGF-1 paradox, ketogenic diets, sauna benefits, and NAD+
Discussion of the paradox of GH/IGF-1 in performance versus longevity, why high IGF-1 promotes growth but may accelerate aging, fasting to reduce IGF-1, and the role of mTOR in aging
#21 - Tom Dayspring Part II:Lipid metrics, measurements, and cholesterol regulation
Lipidology 101 covering lipoprotein structure and function, NMR technology for measuring particles, why LDL-P and ApoB matter more than LDL-C, and cholesterol synthesis pathways
An overview of mTOR and IGF-1 | Peter Attia
How mTOR and IGF-1 growth pathways must remain balanced for muscle repair while limiting accelerated aging, the role of amino acids in regulating these pathways, and implications for cancer risk
Assessing cardiovascular risk (Lipid Series Part 2) | Tom Dayspring
Dr. Dayspring explains which lipid tests matter and which don't, why ApoB is superior to LDL-C, whether LDL particle size matters, HDL-C utility, triglyceride importance, and how to request advanced testing
Essential Cardiovascular Risk Laboratory Analysis | Tom Dayspring
Lipidologist explains that having too many ApoB-containing lipoproteins is a causal risk factor for atherosclerosis, optimal ApoB targets (under 60 mg/dL), and when pharmacologic therapy is needed
Essential Fatty Acids, Fish &Fish Oil
Why omega-6 arachidonic acid and omega-3 DHA may be the truly essential fatty acids, how excess linoleic acid promotes inflammation, optimal omega-6 to omega-3 ratios, and why fish beats flax
How Industrial Seed Oils Are Making Us Sick
How omega-6 fatty acids give rise to arachidonic acid and pro-inflammatory prostaglandins, the connection between seed oils and IBS/IBD, and why the modern omega-6 to omega-3 ratio of 20:1 drives chronic disease
AMA #14:What lab tests can (and cannot) inform us about longevity
Framework for understanding lab tests for longevity including cardiovascular, cancer, and Alzheimer's markers, plus honorable mentions like Lp-PLA2, homocysteine, hs-CRP, oxLDL, fibrinogen, and ADMA
Dr. Ben Bikman:How To Reverse Insulin Resistance Through Diet, Exercise, &Sleep
Insulin resistance as root cause of type 2 diabetes, obesity, cardiovascular disease, Alzheimer's, fatty liver, and infertility;how insulin affects adiponectin and leptin signaling;practical interventions
Jason Fung, M.D.:Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes
Challenging conventional obesity theory, why insulin resistance causes overeating not the reverse, therapeutic fasting protocols for metabolic health, and kidney disease connection to diabetes
The Science of Blood Testing &Longevity Biomarkers
Comprehensive overview of metabolic biomarkers including fasting glucose, insulin, lipid panels, and how glucagon counterbalances insulin;why standard reference ranges may not indicate optimal health
#167 - Common CBC Abnormalities with Mary Kwok MD
Live episode covering CBC abnormalities including workup of thrombocytopenia, erythrocytosis, leukocytosis, and leukopenia;when to refer to hematology;distinguishing reactive from malignant processes
#291 - CBC Abnormalities Triple Distilled
Condensed review of CBC interpretation including differential diagnosis of high and low values for all cell lines, practical pearls for primary care
#444 - Macrocytosis, Hemolytic Anemia, Myelodysplastic Syndrome
Dr. Alfred Lee discusses workup of elevated MCV, reticulocyte count interpretation in hemolysis, and recognition of myelodysplastic syndrome in primary care
#471 - Iron Deficiency Anemia with Dr. Tom DeLoughery
Hematologist Dr. Tom DeLoughery explains iron studies interpretation, ferritin as acute phase reactant, when to use IV iron, and the connection between iron deficiency and fatigue even without anemia
#491 - Benign Hematology with Brad Beeler
Dr. Brad Beeler covers non-malignant blood disorders including isolated neutropenia workup, thalassemia trait recognition, bleeding disorder evaluation, and when thrombocytopenia needs hematology referral
#399 - Wisely Ordering Autoantibodies (ACP IM 2023)
Dr. Christine Carroll explains when to order ANA, RF, anti-CCP, and other autoantibodies;why indiscriminate testing leads to false positives;first-line labs for suspected rheumatoid arthritis and lupus
#147 - Rheumatoid Arthritis for the Internist
Dr. McLean covers RA diagnosis and management for internists including initial labs (CRP, ESR, RF, anti-CCP), why ANA is not useful for RA screening, treatment goals, and when to refer to rheumatology
#112 - The Re(n)al Truth Behind Proteinuria
Nephrologists explain proteinuria workup including why urine protein-to-creatinine ratio is superior to dipstick, causes of false positives/negatives, nephrotic range thresholds, and when to refer
What's the Deal with Liver Enzymes with Dr. William Carey MD
Hepatologist explains liver enzyme patterns:hepatocellular (ALT/AST elevation) vs cholestatic (ALP/bilirubin elevation), calculating R-value, common causes of mildly elevated enzymes, and workup approach
Liver Function Testing - What Every Question You've Ever Had
Dr. John Poterucha answers common questions about LFT interpretation including isolated GGT elevation, albumin as marker of synthetic function, and distinguishing liver vs bone sources of elevated ALP
#373 - Thyroid function and hypothyroidism:why current diagnosis and treatment fall short | Antonio Bianco
World expert on thyroid physiology explains deiodinase enzymes that convert T4 to T3, why TSH alone misses many cases, the reverse T3 debate, genetic influences on thyroid metabolism, and combination T3/T4 therapy
Freely Filtered Episode:Creatinine and eGFR Deep Dive
NephJC hosts discuss KDIGO guidelines on eGFR calculation, why cystatin C combined with creatinine improves accuracy, limitations of creatinine in muscle mass extremes, and CKD staging
The Role of Advanced Lipid Testing in 2024
Cardiologists discuss why standard lipid panels may miss residual cardiovascular risk, role of apoB and Lp(a), when to order advanced testing, and interpreting discordance between LDL-C and particle number
Lipid Insights:ApoB in Clinical Management of Cardiovascular Risk
National Lipid Association experts discuss the 2024 expert consensus on apolipoprotein B, why apoB predicts ASCVD risk better than LDL-C, treatment targets, and when apoB-LDL discordance matters
Lipid Insights:LDL Cholesterol Management Simplified
NLA President Dr. Willard and Beth Jackson unpack the guidance that lower LDL for longer is better, practical approaches to achieving targets, and when to intensify therapy
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