Leptin
Leptin is a hormone produced by fat cells that signals satiety and long-term energy sufficiency to the hypothalamus. Obesity is typically accompanied by high leptin with leptin resistance, so signals of satiety are not effectively received. Very low leptin, as in severe calorie restriction or lipodystrophy, drives hunger, suppresses reproduction, and slows metabolism.
3 providers include this
Advanced / Specialty Markers
Men:1-5 ng/mL, Women:7-13 ng/mL
What is Leptin?
Leptin is a hormone produced by fat cells that signals satiety and long-term energy sufficiency to the hypothalamus. Obesity is typically accompanied by high leptin with leptin resistance, so signals of satiety are not effectively received. Very low leptin, as in severe calorie restriction or lipodystrophy, drives hunger, suppresses reproduction, and slows metabolism.
Why It Matters
Regulates appetite and metabolism. High levels indicate leptin resistance, common in obesity. Low leptin signals starvation to the brain. Important for understanding weight regulation.
Which Providers Test Leptin?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | ✓ | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| — | $895 | 100+ | |
| — | $1950 | 130+ | |
| ✓ | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| — | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| ✓ | $99 | 100+ |
Frequently Asked Questions
What is Leptin?
Leptin is a hormone produced by fat cells that signals satiety and long-term energy sufficiency to the hypothalamus. Obesity is typically accompanied by high leptin with leptin resistance, so signals of satiety are not effectively received. Very low leptin, as in severe calorie restriction or lipodystrophy, drives hunger, suppresses reproduction, and slows metabolism.
What is the optimal range for Leptin?
The standard reference range for Leptin is Men:1-5 ng/mL, Women:7-13 ng/mL. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include Leptin?
3 out of 22 blood testing providers include Leptin in their panels. This biomarker has limited availability.
What category does Leptin fall under?
Leptin is categorized under Advanced / Specialty Markers. This category includes biomarkers that help assess related aspects of health and wellness.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12