TRT & Hormone Optimization Clinics 2026
Compare TRT and hormone optimization clinics. Pricing, medications, lab work, and provider support compared.
Pricing & Plans Comparison
Complete cost breakdown including monthly fees, lab work, and medications. Updated Jan 2026
| Provider | Monthly Cost | Annual Cost | Labs Included | Prescriber Type | State Availability |
|---|---|---|---|---|---|
| $225/mo | $2700/yr | Comprehensive hormone panel | MD/DO | 47 states (not NY/NJ/RI) | |
| $99/mo | $1188/yr | Basic hormone panel | MD/DO | All 50 states via telemedicine | |
| $99/mo | $1188/yr | Basic hormone panel | NP/PA | 45 states | |
| $149/mo | $1788/yr | Comprehensive hormone panel (40+ biomarkers) | MD/DO | 47 states | |
| $199/mo | $2388/yr | Basic hormone panel | MD (Urologist) | 45 states | |
| $99/mo | $1188/yr | Comprehensive hormone panel | MD | 40+ states |
Medications & Treatments
Compare available medications, pharmacy options, and additional treatments offered by each provider.
| Provider | Medications Offered | Pharmacy Type | Injection Training | Patient Portal |
|---|---|---|---|---|
| Marek Health | Testosterone, HCG, AI, Nandrolone, Oxandrolone | In-house compounding | Yes | Yes |
| Defy Medical | Testosterone, HCG, AI, Clomid | Partner pharmacies | Yes | Yes |
| TRT Nation | Testosterone cypionate, HCG, AI | Partner pharmacies | Yes | Yes |
| Hone Health | Testosterone (injections/cream/troches), Clomiphene, Enclomiphene, Anastrozole | Partner pharmacies | Yes | Yes |
| Fountain TRT | Testosterone cream | Partner pharmacies | No | Yes |
| Peter Uncaged MD | Testosterone, HCG, AI, Peptides, GH | In-house compounding | Yes | Yes |
Provider Details
In-depth look at each TRT clinic including features, pricing, and who it's best for.
Marek Health
Key Features
Hormone optimization focus, custom protocols, expert consultations, blood work included
Details
Monthly fee includes meds, labs, and consultations.
Defy Medical
Key Features
Operating since 2013, flexible protocols, no subscription/contract
Details
Pay-per-service model (no monthly subscription). Initial consult $250-350, follow-ups $100-200. Average ~$250/mo year 1, under $200/mo after. Includes testosterone, HCG, labs, consults. One of the original TRT clinics.
TRT Nation
Key Features
$99/month all-inclusive, unlimited doctor access, supplies and shipping included
Details
$99/month includes testosterone cypionate, injection supplies, shipping, and unlimited doctor consultations. Lab work:patients can supply outside labs or run through clinic ($129 lab fee). Blood work required after first 10 weeks, then 6 months, then annually. HSA/FSA eligible.
Hone Health
Key Features
At-home testing option, 40+ biomarkers, retesting every 90 days on Premium, 5-day consult and 10-day med delivery
Details
Premium $149/mo (full TRT, testing, consults, retesting every 90 days), Plus $129/mo (hormone optimization with labs), Basic $25/mo (40+ biomarker testing every 6 months, consult purchases a la carte). Medications billed separately:testosterone injections $28/mo, cream/troches $60/mo, clomiphene $38/mo, enclomiphene $42/mo, anastrozole $22/mo. Initial diagnostic $65.
Fountain TRT
Key Features
All-inclusive testosterone cream (no injections), led by board-certified urologists, telehealth consults
Details
$199/month all-inclusive (medication, video visits, labs, ongoing medical support). Topical testosterone cream delivered monthly (applied to shoulder daily). Led by Dr. Doron Stember, board-certified urologist. Follow-ups every 3-6 months. Transparent flat pricing, cancel anytime.
Peter Uncaged MD
Key Features
Now PeterMD, tiered pricing, advanced protocols, peptide options
Details
Rebranded to PeterMD. $99/mo or $87/mo half-yearly ($522). Includes meds, supplies, shipping, unlimited consults. Labs $215 first year, $96/yr after. 6-month initial commitment. Price match guarantee (20% off).
Important Considerations
- Medical supervision required: TRT requires ongoing blood work and physician monitoring
- Fertility impact: Exogenous testosterone can affect sperm production - discuss with your provider
- Not for everyone: TRT is not appropriate for those with prostate cancer, severe sleep apnea, or certain cardiovascular conditions
- Commitment: TRT is typically a long-term or lifelong therapy - understand the commitment before starting
Frequently Asked Questions
What is TRT and who needs it?
Testosterone Replacement Therapy (TRT) is a medical treatment for men with clinically low testosterone levels (hypogonadism). Symptoms can include fatigue, low libido, depression, difficulty building muscle, and cognitive issues. TRT is typically recommended when blood tests confirm low testosterone and symptoms are present.
How much does TRT cost per month?
TRT costs range from $99/month (TRT Nation or Defy Medical) to $225+/month (Marek Health - comprehensive protocols). Most services fall in the $99-200/month range including medications, labs, and consultations. HSA/FSA funds can often be used.
Can I get TRT online?
Yes, all providers listed here offer telemedicine consultations. You'll complete blood work at a local lab, have a video consultation with a licensed provider, and receive medications shipped to your door. Most services operate in 40+ states.
What medications are typically prescribed?
Common TRT medications include testosterone cypionate or enanthate (injectable), HCG (to maintain fertility and testicular function), aromatase inhibitors (to control estrogen), and sometimes clomiphene (an alternative to testosterone). Some clinics also offer peptides and growth hormone protocols.
How often do I need blood work?
Most providers require blood work every 3-6 months to monitor testosterone levels, hematocrit, PSA, estradiol, and other markers. Many clinics include labs in their monthly fee, while others charge separately.
Is TRT covered by insurance?
Some insurance plans cover TRT if you have a diagnosis of hypogonadism. However, most online TRT clinics operate on a cash-pay model. HSA/FSA funds are typically eligible for TRT expenses.
What testosterone levels qualify for TRT?
Most clinics consider total testosterone below 300 ng/dL as low, though symptoms matter more than numbers alone. Some men experience low-T symptoms at 400-500 ng/dL, while others feel fine at 300. Free testosterone, SHBG, and symptoms are also considered. Online TRT clinics may have different thresholds than traditional endocrinologists.
Will TRT affect my fertility?
Yes, exogenous testosterone suppresses natural testosterone production and can significantly reduce sperm count, potentially causing temporary infertility. HCG is often prescribed alongside testosterone to maintain testicular function and fertility. If preserving fertility is important, discuss this with your provider before starting - alternatives like clomiphene may be recommended instead.
How long does it take to see results from TRT?
Timeline varies by symptom:libido and energy often improve within 3-6 weeks, mood and cognitive benefits appear around 6-12 weeks, body composition changes (muscle gain, fat loss) take 3-6 months, and maximum benefits are typically seen at 12+ months. Optimal dosing may require several adjustments based on blood work and symptom response.
What are the potential side effects of TRT?
Common side effects include acne, increased hematocrit (thickened blood), water retention, and testicular shrinkage. Elevated estrogen can cause gynecomastia (breast tissue growth) - managed with aromatase inhibitors. More serious risks include sleep apnea worsening, cardiovascular concerns in some populations, and fertility suppression. Regular blood work monitors these issues.
Monitor Your Hormone Optimization
Track your TRT progress with comprehensive blood testing to ensure optimal levels and safety.
Compare Blood Test ServicesImportant Disclaimer
This comparison is for informational purposes only and is not medical advice. TRT is a prescription medication that requires physician oversight. Prices are based on January 2026 data and may vary. Always consult with a healthcare provider before starting any hormone therapy.