SHBG (Sex Hormone Binding Globulin)
SHBG is a liver-made protein that binds testosterone and estrogen and regulates how much circulates freely. Low SHBG is associated with obesity, insulin resistance, fatty liver, and hypothyroidism, while high SHBG occurs in hyperthyroidism, liver disease, and with oral estrogen use. Changes in SHBG affect the interpretation of total testosterone and estradiol.
15 of 22 providers
Sex Hormones (Male)
regulating how much is available for tissues to use. Low SHBG is associated with insulin resistance;high SHBG can cause symptoms of low testosterone.
What is SHBG (Sex Hormone Binding Globulin)?
SHBG is a liver-made protein that binds testosterone and estrogen and regulates how much circulates freely. Low SHBG is associated with obesity, insulin resistance, fatty liver, and hypothyroidism, while high SHBG occurs in hyperthyroidism, liver disease, and with oral estrogen use. Changes in SHBG affect the interpretation of total testosterone and estradiol.
Why It Matters
Binds testosterone and estrogen, regulating how much is available for tissues to use. Low SHBG is associated with insulin resistance;high SHBG can cause symptoms of low testosterone.
Which Providers Test SHBG (Sex Hormone Binding Globulin)?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | ✓ | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | ✓ | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| ✓ | $349 | 100+ | |
| ✓ | $829 | 54 | |
 Function Health | ✓ | $365 | 160+ |
| — | $250 | 65 | |
| ✓ | $495 | 80+ | |
| ✓ | $895 | 100+ | |
| ✓ | $1950 | 130+ | |
| ✓ | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| ✓ | $124 | 60 | |
| ✓ | $349 | 130+ | |
| ✓ | $349 | 80+ | |
| ✓ | $375 | 85 | |
| ✓ | $700 | 128 | |
| ✓ | $99 | 100+ |
Frequently Asked Questions
What is SHBG (Sex Hormone Binding Globulin)?
SHBG is a liver-made protein that binds testosterone and estrogen and regulates how much circulates freely. Low SHBG is associated with obesity, insulin resistance, fatty liver, and hypothyroidism, while high SHBG occurs in hyperthyroidism, liver disease, and with oral estrogen use. Changes in SHBG affect the interpretation of total testosterone and estradiol.
What is the optimal range for SHBG (Sex Hormone Binding Globulin)?
The standard reference range for SHBG (Sex Hormone Binding Globulin) is regulating how much is available for tissues to use. Low SHBG is associated with insulin resistance;high SHBG can cause symptoms of low testosterone.. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include SHBG (Sex Hormone Binding Globulin)?
15 out of 22 blood testing providers include SHBG (Sex Hormone Binding Globulin) in their panels. This biomarker is widely available across major providers.
What category does SHBG (Sex Hormone Binding Globulin) fall under?
SHBG (Sex Hormone Binding Globulin) is categorized under Sex Hormones (Male). This category includes biomarkers that help assess related aspects of health and wellness.
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Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12