APOE Genotype
APOE genotype identifies the variants of the apolipoprotein E gene (E2, E3, E4) that influence lipid metabolism and brain function. Carrying one APOE4 allele raises Alzheimer disease risk about threefold, and two alleles raise it substantially more. APOE4 also affects LDL cholesterol and cardiovascular risk, and genotype is generally tested once because it does not change.
1 providers include this
Advanced / Specialty Markers
E2/E3, E3/E3 preferred;E3/E4, E4/E4 higher risk
What is APOE Genotype?
APOE genotype identifies the variants of the apolipoprotein E gene (E2, E3, E4) that influence lipid metabolism and brain function. Carrying one APOE4 allele raises Alzheimer disease risk about threefold, and two alleles raise it substantially more. APOE4 also affects LDL cholesterol and cardiovascular risk, and genotype is generally tested once because it does not change.
Why It Matters
APOE4 variant increases Alzheimer's disease risk 3-12x. Also affects cholesterol metabolism and cardiovascular risk. Guides lifestyle and preventive interventions.
Which Providers Test APOE Genotype?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | — | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| — | $895 | 100+ | |
| ✓ | $1950 | 130+ | |
| — | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| — | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| — | $99 | 100+ |
Frequently Asked Questions
What is APOE Genotype?
APOE genotype identifies the variants of the apolipoprotein E gene (E2, E3, E4) that influence lipid metabolism and brain function. Carrying one APOE4 allele raises Alzheimer disease risk about threefold, and two alleles raise it substantially more. APOE4 also affects LDL cholesterol and cardiovascular risk, and genotype is generally tested once because it does not change.
What is the optimal range for APOE Genotype?
The standard reference range for APOE Genotype is E2/E3, E3/E3 preferred;E3/E4, E4/E4 higher risk. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include APOE Genotype?
1 out of 22 blood testing providers include APOE Genotype in their panels. This biomarker has limited availability.
What category does APOE Genotype fall under?
APOE Genotype is categorized under Advanced / Specialty Markers. This category includes biomarkers that help assess related aspects of health and wellness.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12