Osteocalcin
Osteocalcin is a noncollagenous protein made by osteoblasts during bone formation and is released into blood as a marker of bone turnover. Elevated levels occur during rapid bone growth, fracture healing, and high-turnover conditions such as hyperparathyroidism, while low levels suggest reduced bone formation. Its undercarboxylated form has also been linked to glucose metabolism.
1 providers include this
Advanced / Specialty Markers
9-42 ng/mL
What is Osteocalcin?
Osteocalcin is a noncollagenous protein made by osteoblasts during bone formation and is released into blood as a marker of bone turnover. Elevated levels occur during rapid bone growth, fracture healing, and high-turnover conditions such as hyperparathyroidism, while low levels suggest reduced bone formation. Its undercarboxylated form has also been linked to glucose metabolism.
Why It Matters
Indicates rate of bone formation. Low levels suggest poor bone building. Also affects glucose metabolism and testosterone. Marker for osteoporosis treatment effectiveness.
Which Providers Test Osteocalcin?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | ✓ | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| — | $895 | 100+ | |
| — | $1950 | 130+ | |
| — | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| — | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| — | $99 | 100+ |
Frequently Asked Questions
What is Osteocalcin?
Osteocalcin is a noncollagenous protein made by osteoblasts during bone formation and is released into blood as a marker of bone turnover. Elevated levels occur during rapid bone growth, fracture healing, and high-turnover conditions such as hyperparathyroidism, while low levels suggest reduced bone formation. Its undercarboxylated form has also been linked to glucose metabolism.
What is the optimal range for Osteocalcin?
The standard reference range for Osteocalcin is 9-42 ng/mL. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include Osteocalcin?
1 out of 22 blood testing providers include Osteocalcin in their panels. This biomarker has limited availability.
What category does Osteocalcin fall under?
Osteocalcin is categorized under Advanced / Specialty Markers. This category includes biomarkers that help assess related aspects of health and wellness.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12