Pregnenolone
Pregnenolone is synthesized from cholesterol in the adrenal glands, gonads, and brain and serves as the master precursor to DHEA, cortisol, aldosterone, testosterone, and estrogen. Levels decline with age and chronic stress and have been linked with cognition, memory, and mood. Low levels may indicate impaired steroidogenesis in adrenal dysfunction.
3 providers include this
Sex Hormones (Male)
10-200 ng/dL
What is Pregnenolone?
Pregnenolone is synthesized from cholesterol in the adrenal glands, gonads, and brain and serves as the master precursor to DHEA, cortisol, aldosterone, testosterone, and estrogen. Levels decline with age and chronic stress and have been linked with cognition, memory, and mood. Low levels may indicate impaired steroidogenesis in adrenal dysfunction.
Why It Matters
Declines with age and chronic stress. Low levels associated with fatigue, memory problems, and decreased stress resilience. Precursor to DHEA, cortisol, testosterone, and estrogen.
Which Providers Test Pregnenolone?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | ✓ | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| ✓ | $895 | 100+ | |
| ✓ | $1950 | 130+ | |
| — | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| — | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| — | $99 | 100+ |
Frequently Asked Questions
What is Pregnenolone?
Pregnenolone is synthesized from cholesterol in the adrenal glands, gonads, and brain and serves as the master precursor to DHEA, cortisol, aldosterone, testosterone, and estrogen. Levels decline with age and chronic stress and have been linked with cognition, memory, and mood. Low levels may indicate impaired steroidogenesis in adrenal dysfunction.
What is the optimal range for Pregnenolone?
The standard reference range for Pregnenolone is 10-200 ng/dL. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include Pregnenolone?
3 out of 22 blood testing providers include Pregnenolone in their panels. This biomarker has limited availability.
What category does Pregnenolone fall under?
Pregnenolone is categorized under Sex Hormones (Male). This category includes biomarkers that help assess related aspects of health and wellness.
Want to support healthy hormone levels? YouBoost rates lifestyle interventions by evidence. Track stress and recovery trends with HRV Zone.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12