Signatera by Natera vs Prenetics CIRCLE
Side-by-side comparison of cancer screening tests.
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Test Performance
| Feature | Signatera by Natera | Prenetics CIRCLE |
|---|---|---|
| Price | Variable | $Varies |
| Cancers Detected | Patient-specific | 35+ cancer risk reports |
| Sensitivity | Varies by cancer | Variable |
| Specificity | PPV >98% | Variable |
| Sample Type | Blood draw | Saliva/cheek swab |
| FDA Status | CLIA LDT (CDx approved only for bladder cancer) | Not FDA approved |