Shield by Guardant vs Signatera by Natera
Side-by-side comparison of cancer screening tests.
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Test Performance
| Feature | Shield by Guardant | Signatera by Natera |
|---|---|---|
| Price | $1495 | Variable |
| Cancers Detected | Colorectal only | Patient-specific |
| Sensitivity | 83% for CRC (54.5-65% Stage I) | Varies by cancer |
| Specificity | 90% | PPV >98% |
| Sample Type | Blood draw | Blood draw |
| FDA Status | FDA approved (CRC test only) | CLIA LDT (CDx approved only for bladder cancer) |