Shield by Guardant vs Signatera by Natera

Side-by-side comparison of cancer screening tests.

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Shield by Guardant

FDA approved
$1495

Colorectal only

Signatera by Natera

FDA approved (MRD)
Variable

Patient-specific

Test Performance

FeatureShield by GuardantSignatera by Natera
Price$1495Variable
Cancers DetectedColorectal onlyPatient-specific
Sensitivity84% for CRCVaries by cancer
Specificity90%>99.8%
Sample TypeBlood drawBlood draw
FDA StatusFDA approvedFDA approved (MRD)

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