Which is cheaper, Shield by Guardant or Signatera by Natera?

Shield by Guardant is more affordable at $895 compared to Signatera by Natera at $Variable.

What is Shield by Guardant best for?

Shield by Guardant is best for:Adults 45+ wanting non-invasive CRC screening. Key features include:FDA-approved for CRC|Medicare coverage|Blood-based alternative to colonoscopy|Primary screening option

What is Signatera by Natera best for?

Signatera by Natera is best for:Cancer patients monitoring for recurrence. Key features include:Personalized cancer monitoring|Detects recurrence early|Treatment response tracking|Tumor-informed approach

What's the difference between Shield by Guardant and Signatera by Natera?

Shield by Guardant and Signatera by Natera are both cancer screening services. Compare their pricing, features, and methodology to find the best fit for your needs.

Shield by Guardant vs Signatera by Natera

Side-by-side comparison of cancer screening tests.

← Back to Cancer Screening

Shield by Guardant

FDA approved

$895

Colorectal only

Signatera by Natera

FDA approved (MRD)

Variable

Patient-specific

Test Performance

Feature	Shield by Guardant	Signatera by Natera
Price	$895	Variable
Cancers Detected	Colorectal only	Patient-specific
Sensitivity	84% for CRC	Varies by cancer
Specificity	90%	>99.8%
Sample Type	Blood draw	Blood draw
FDA Status	FDA approved	FDA approved (MRD)

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