Shield by Guardant vs Prenetics CIRCLE

Side-by-side comparison of cancer screening tests.

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Shield by Guardant

FDA approved (CRC test only)
$1495

Colorectal only

Prenetics CIRCLE

Not FDA approved
$Varies

35+ cancer risk reports

Test Performance

FeatureShield by GuardantPrenetics CIRCLE
Price$1495$Varies
Cancers DetectedColorectal only35+ cancer risk reports
Sensitivity83% for CRC (54.5-65% Stage I)Variable
Specificity90%Variable
Sample TypeBlood drawSaliva/cheek swab
FDA StatusFDA approved (CRC test only)Not FDA approved

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