Galleri by GRAIL vs Signatera by Natera
Side-by-side comparison of cancer screening tests.
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Test Performance
| Feature | Galleri by GRAIL | Signatera by Natera |
|---|---|---|
| Price | $949 | Variable |
| Cancers Detected | 50+ cancers | Patient-specific |
| Sensitivity | >70% for the 12 deadliest cancers | Varies by cancer |
| Specificity | 99.6% (0.4% false positive rate) | PPV >98% |
| Sample Type | Blood draw | Blood draw |
| FDA Status | Not FDA approved (PMA under review;advisory panel Sept 2026) | CLIA LDT (CDx approved only for bladder cancer) |