Which is cheaper, Cologuard by Exact Sciences or Signatera by Natera?

Cologuard by Exact Sciences is more affordable at $649 compared to Signatera by Natera at $Variable.

What is Cologuard by Exact Sciences best for?

Cologuard by Exact Sciences is best for:Adults 45+ preferring home collection for CRC screening. Key features include:At-home stool collection|High sensitivity for CRC|Insurance covered|Established track record

What is Signatera by Natera best for?

Signatera by Natera is best for:Cancer patients monitoring for recurrence. Key features include:Personalized cancer monitoring|Detects recurrence early|Treatment response tracking|Tumor-informed approach

What's the difference between Cologuard by Exact Sciences and Signatera by Natera?

Cologuard by Exact Sciences and Signatera by Natera are both cancer screening services. Compare their pricing, features, and methodology to find the best fit for your needs.

Cologuard by Exact Sciences vs Signatera by Natera

Side-by-side comparison of cancer screening tests.

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Cologuard by Exact Sciences

FDA approved

$649

Colorectal only

Signatera by Natera

FDA approved (MRD)

Variable

Patient-specific

Test Performance

Feature	Cologuard by Exact Sciences	Signatera by Natera
Price	$649	Variable
Cancers Detected	Colorectal only	Patient-specific
Sensitivity	92% for CRC	Varies by cancer
Specificity	87%	>99.8%
Sample Type	Stool sample	Blood draw
FDA Status	FDA approved	FDA approved (MRD)

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