Which is cheaper, Cologuard by Exact Sciences or Signatera by Natera?

Cologuard by Exact Sciences is more affordable at $599 compared to Signatera by Natera at $Variable.

What is Cologuard by Exact Sciences best for?

Cologuard by Exact Sciences is best for:Adults 45+ preferring home collection for CRC screening. Key features include:At-home stool collection|High sensitivity for CRC|Insurance covered|Established track record

What is Signatera by Natera best for?

Signatera by Natera is best for:Cancer patients monitoring for recurrence. Key features include:Personalized cancer monitoring|Detects recurrence early|Treatment response tracking|Tumor-informed approach

What's the difference between Cologuard by Exact Sciences and Signatera by Natera?

Cologuard by Exact Sciences and Signatera by Natera are both cancer screening services. Compare their pricing, features, and methodology to find the best fit for your needs.

Cologuard by Exact Sciences vs Signatera by Natera

Side-by-side comparison of cancer screening tests.

← Back to Cancer Screening

Cologuard by Exact Sciences

FDA approved

$599

Colorectal only

Signatera by Natera

CLIA LDT (CDx approved only for bladder cancer)

Variable

Patient-specific

Test Performance

Feature	Cologuard by Exact Sciences	Signatera by Natera
Price	$599	Variable
Cancers Detected	Colorectal only	Patient-specific
Sensitivity	95% for CRC	Varies by cancer
Specificity	94%	PPV >98%
Sample Type	Stool sample	Blood draw
FDA Status	FDA approved	CLIA LDT (CDx approved only for bladder cancer)

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Cologuard by Exact Sciences vs Signatera by Natera

Cologuard by Exact Sciences

Signatera by Natera

Test Performance

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