Systemic Inflammation Index (SII)
The Systemic Inflammation Index is calculated from platelet, neutrophil, and lymphocyte counts on a standard CBC. It reflects combined inflammatory and thrombotic activity and has been linked with cardiovascular events, cancer prognosis, and overall mortality. SII offers more information than single cell counts and can be tracked over time to follow inflammation.
2 providers include this
Additional Specialized Tests
<500 optimal, >1000 elevated
What is Systemic Inflammation Index (SII)?
The Systemic Inflammation Index is calculated from platelet, neutrophil, and lymphocyte counts on a standard CBC. It reflects combined inflammatory and thrombotic activity and has been linked with cardiovascular events, cancer prognosis, and overall mortality. SII offers more information than single cell counts and can be tracked over time to follow inflammation.
Why It Matters
Calculated from platelet, neutrophil, and lymphocyte counts. Elevated SII predicts cardiovascular events, cancer prognosis, and all-cause mortality. More comprehensive than single inflammatory markers.
Which Providers Test Systemic Inflammation Index (SII)?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | ✓ | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | — | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| — | $895 | 100+ | |
| — | $1950 | 130+ | |
| — | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| ✓ | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| — | $99 | 100+ |
Frequently Asked Questions
What is Systemic Inflammation Index (SII)?
The Systemic Inflammation Index is calculated from platelet, neutrophil, and lymphocyte counts on a standard CBC. It reflects combined inflammatory and thrombotic activity and has been linked with cardiovascular events, cancer prognosis, and overall mortality. SII offers more information than single cell counts and can be tracked over time to follow inflammation.
What is the optimal range for Systemic Inflammation Index (SII)?
The standard reference range for Systemic Inflammation Index (SII) is <500 optimal, >1000 elevated. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include Systemic Inflammation Index (SII)?
2 out of 22 blood testing providers include Systemic Inflammation Index (SII) in their panels. This biomarker has limited availability.
What category does Systemic Inflammation Index (SII) fall under?
Systemic Inflammation Index (SII) is categorized under Additional Specialized Tests. This category includes biomarkers that help assess related aspects of health and wellness.
Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12