Methylmalonic Acid
Methylmalonic acid accumulates when vitamin B12 is insufficient for its role as a cofactor in converting methylmalonyl-CoA to succinyl-CoA. It is a more sensitive and specific indicator of functional B12 deficiency than serum B12 alone and can detect tissue-level deficiency even when serum B12 appears normal. Levels fall with B12 repletion.
Optimal range: who says what
Institutions, researchers and practitioners draw the line in different places. Each position is listed with who holds it and, where a document states it, a link. How we verify ranges.
- Institution or study≤254-317 nmol/L depending on age (0.25-0.32 nmol/mL)CDC NHANES age-specific reference intervals (Mineva et al. 2019, Am J Clin Nutr)Upper limits in B12-replete adults with normal kidney function: 254 (20-39 y), 293 (40-59 y), 281 (60-69 y) and 317 nmol/L (70+); MMA rises with age and with reduced kidney function
- Lab reference interval0.00-0.40 nmol/mLWhat a lab report flags against. A lab interval is not an optimal target.
1 providers include this
Vitamins & Nutrients
Why Methylmalonic Acid matters
More sensitive and specific marker for vitamin B12 deficiency than serum B12 alone. Elevated levels confirm functional B12 deficiency even when serum B12 appears normal.
Which Providers Test Methylmalonic Acid?
Of the panels we itemize, only Ultrahuman Blood Vision Annual ($499/year, 100+ biomarkers) includes Methylmalonic Acid.
1 panel that includes it, cheapest first
| Provider | Annual Cost | Total Biomarkers | $/Biomarker |
|---|---|---|---|
| $499 | 100+ | $4.99 |
$/Biomarker is annual cost divided by the panel's advertised biomarker count, not the price of this one test. We track 23 blood test providers (32 plans); 21 of those plans are itemized marker by marker. Compare all of them.
20 itemized panels do not include Methylmalonic Acid
Superpower · WHOOP Advanced Labs · Labcorp OnDemand · Life Extension Elite · Everlywell · Mito Health · InsideTracker · Function Health · Marek Health Base · Marek Health Comprehensive · Marek Health Complete · Marek Health Executive · Blueprint · Empirical Health · Oura Health Panels · SiPhox Health · Hims Labs · Healthspan · Vitality Blueprint Standard · Vitality Blueprint Elite
11 providers not itemized in our matrix
We have not itemized these marker by marker (some sell tests one at a time), so this page cannot say whether they offer Methylmalonic Acid. Check with them directly.
Life Extension Standard · Quest Health · Ultrahuman Blood Vision · Lifeforce · Hundred Health · Personalabs · Walk-In Lab · HealthLabs · WHOOP Specialized Panels · Marek Health Essential · Vitality Blueprint Upload
Frequently Asked Questions
What is the optimal range for Methylmalonic Acid?
Published position: ≤254-317 nmol/L depending on age (0.25-0.32 nmol/mL) (CDC NHANES age-specific reference intervals (Mineva et al. 2019, Am J Clin Nutr)). Lab reference interval: 0.00-0.40 nmol/mL. That is what a lab report flags against, not an optimal target.
Which blood test providers include Methylmalonic Acid?
1 of the 21 blood testing panels we itemize marker by marker include Methylmalonic Acid in their panels. This biomarker has limited availability.
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Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed Sep 23, 2026 · First published Mar 5, 2026