Methylmalonic Acid
Methylmalonic acid accumulates when vitamin B12 is insufficient for its role as a cofactor in converting methylmalonyl-CoA to succinyl-CoA. It is a more sensitive and specific indicator of functional B12 deficiency than serum B12 alone and can detect tissue-level deficiency even when serum B12 appears normal. Levels fall with B12 repletion.
1 providers include this
Vitamins &Nutrients
0.00-0.40 nmol/mL
What is Methylmalonic Acid?
Methylmalonic acid accumulates when vitamin B12 is insufficient for its role as a cofactor in converting methylmalonyl-CoA to succinyl-CoA. It is a more sensitive and specific indicator of functional B12 deficiency than serum B12 alone and can detect tissue-level deficiency even when serum B12 appears normal. Levels fall with B12 repletion.
Why It Matters
More sensitive and specific marker for vitamin B12 deficiency than serum B12 alone. Elevated levels confirm functional B12 deficiency even when serum B12 appears normal.
Which Providers Test Methylmalonic Acid?
Full Provider Comparison
| Provider | Includes | Annual Cost | Biomarkers |
|---|---|---|---|
 Superpower | — | $199 | 100+ (150 with ratios) |
 WHOOP Advanced Labs | — | $349 | 65 |
 Labcorp OnDemand | — | $398 | 40+ |
| — | $486 | 40+ | |
| — | $449 | 288 | |
| — | $349 | 100+ | |
| — | $829 | 54 | |
 Function Health | — | $365 | 160+ |
| — | $250 | 65 | |
| — | $495 | 80+ | |
| — | $895 | 100+ | |
| — | $1950 | 130+ | |
| — | $375 | 95+ | |
| — | $Varies | 75+ | |
| — | $190 | 100+ | |
| — | $99 | 50 | |
| — | $124 | 60 | |
| — | $349 | 130+ | |
| — | $349 | 80+ | |
| — | $375 | 85 | |
| — | $700 | 128 | |
| ✓ | $99 | 100+ |
Frequently Asked Questions
What is Methylmalonic Acid?
Methylmalonic acid accumulates when vitamin B12 is insufficient for its role as a cofactor in converting methylmalonyl-CoA to succinyl-CoA. It is a more sensitive and specific indicator of functional B12 deficiency than serum B12 alone and can detect tissue-level deficiency even when serum B12 appears normal. Levels fall with B12 repletion.
What is the optimal range for Methylmalonic Acid?
The standard reference range for Methylmalonic Acid is 0.00-0.40 nmol/mL. Optimal ranges may differ based on individual health goals and expert recommendations.
Which blood test providers include Methylmalonic Acid?
1 out of 22 blood testing providers include Methylmalonic Acid in their panels. This biomarker has limited availability.
What category does Methylmalonic Acid fall under?
Methylmalonic Acid is categorized under Vitamins &Nutrients. This category includes biomarkers that help assess related aspects of health and wellness.
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Medical Disclaimer
This information is for educational purposes only and is not medical advice. Always consult with a qualified healthcare provider about your specific health needs.
Last reviewed:2026-04-12